USMLE Step 1 & 2 Study Guide

Comprehensive coverage of every major sub-topic on the USMLE Step 1 & 2, free. Read the rule, the named traps, and the worked examples. Then drill the same sub-topic adaptively in the app.

Anatomy & Embryology

Embryonic Development and Congenital Defects
Gross Anatomy: Head and Neck, Neuroanatomy
Gross Anatomy: Thorax, Abdomen, Pelvis
Gross Anatomy: Upper and Lower Limbs

Behavioral Sciences & Biostatistics

Bias and Confounding
Grief, Adjustment, and Psychiatric Screening
Patient-interviewing and Communication Ethics
Sensitivity, Specificity, PPV, NPV
Study Design: Cohort, Case-control, RCT

Biochemistry & Molecular Biology

Carbohydrate Metabolism
DNA/RNA Replication, Transcription, Translation
Enzyme Kinetics and Cofactors
Inborn Errors of Metabolism
Lipid and Amino Acid Metabolism

Cardiovascular System

Arrhythmias and ECG Interpretation
Heart Failure
Ischemic Heart Disease and MI
Valvular Disease

Microbiology & Immunology

Antibacterial Drug Targets and Resistance
Bacterial Structure and Pathogenesis
Fungi and Parasites
Hypersensitivity and Immunodeficiency
Innate and Adaptive Immunity
Viruses and Antivirals

Pathology & Pathophysiology

Cellular Injury and Adaptation
Genetic Disorders (mendelian and Chromosomal)
Hemodynamic Disorders (shock, Edema, Thrombosis)
Inflammation and Repair
Neoplasia: Tumor Grading, Staging, Markers

Pharmacology

Adverse Effects and Drug Interactions
Antibiotics and Antivirals
Autonomic Nervous System Drugs
Cardiovascular Drugs
Pharmacodynamics and Dose-response
Pharmacokinetics (ADME)

Physiology

Cardiovascular Physiology: Preload, Afterload, Contractility
Endocrine Physiology: Hormone Feedback
Neurophysiology: Reflexes, CNS Function
Renal Physiology: Filtration, Acid-base
Respiratory Physiology: Mechanics, Gas Exchange

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